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PulseNet (the National Molecular Subtyping Network for Foodborne Disease Surveillance) is an early warning system for outbreaks of foodborne diseases. The network has participants from public-health laboratories in all 50 states, federal regulatory agencies, and some state agricultural laboratories and is coordinated by CDC. PulseNet contributes to the identification and investigation of outbreaks of foodborne and bacterial diseases through comparison of the molecular “fingerprints” of foodborne pathogens from patients and their food, water, and animal sources. The network can identify and label each fingerprint pattern to permit the rapid comparison of these patterns with others in the PulseNet database.