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The Foodborne Disease Active Surveillance Network (FoodNet) provides a network for responding to new and emerging foodborne diseases of national importance, monitoring the burden of foodborne disease, and identifying the sources of specific foodborne diseases. It consists of active surveillance and related epidemiological studies, which help public-health officials better understand the epidemiology of foodborne diseases in the United States. Participating FoodNet sites may also be employed to coordinate enhanced surveillance and epidemiologic investigation if a novel foodborne disease threat is suspected in order to more rapidly identify the source and extent of the threat.